INTRODUCTION: The study was conducted to define the determinants of suboptimal BLOOD PRESSURE (BP) CONTROL among hypertensive patients under treatment and explore a predictive model for detecting the patients at risk for increased BP.METHODS: We enrolled 97 patients (40 males, 57 females) under treatment for hypertension between June 2006 and May 2007 in Shafa hospital, Kerman, Iran. BP was measured at clinic twice within 5-minute intervals. After setting up ambulatory BLOOD PRESSURE monitoring (ABPM), BP was measured at 30-minute intervals during the day and 60-minute intervals during the night. The frequency of increased BP (more than 140/90 mmHg) was included in a regression model as dependent variable and all the others such as age, sex, body mass index (BMI), drugs and baseline clinical measurements as the predictors.RESULTS: Increased BP was detected in 44% (95% CI: 38.79%-49.65%) of all measurements during 24-hour monitoring. The frequency of increased BP had a significant relationship with BMI (β=0.35, P=0.001). Clinic's pulse PRESSURE was a significant predicting factor for BP increase (P=0.02).CONCLUSION: BMI and pulse PRESSURE are the best predictors for being hypertensive during lifetime. Ineffective treatment of hypertension is frequent among the hypertensive patients.